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Cell & Gene Therapy: Heatmap & Industry Update

Cell & Gene Therapy: Heatmap & Industry Update

The cell and gene therapy manufacturing sphere continues to mature rapidly, with a growing number of companies moving towards commercialising products. This report includes a European Heatmap which provides a high level overview of the latest developments in the European cell and gene therapy manufacturing space, in addition to an detailed industry update which provides information about therapy development throughout Europe.

Addressing Scalability Challenges in Cell Therapy Manufacturing

Addressing Scalability Challenges in Cell Therapy Manufacturing

As cell and gene therapy production continues to move towards commercialisation, it faces new challenges relating to the scalability of manufacturing processes. Both autologous and allogeneic therapies hold their own unique obstacles relating to production and treatment; and the promise of personalised medicines is not without hindrances related to both cost and availability.

We interviewed Andrew Finnerty, General Manager, CCMI Ireland at NUI Galway to discuss this topic in more detail and build a better understanding of how the rapid expansion of this market has brought about new challenges relating to manufacturing scalability , and what will this mean for the future of personalised cell and gene therapies. 


Overcoming Manufacturing Challenges in the Race to Market

Overcoming Manufacturing Challenges in the Race to Market

Fast on its way to becoming a multibillion-dollar market, the global cell and gene therapy industry is booming. However, challenges mean that almost three decades after the first gene therapy trial, only three gene therapies have been approved in the EU and one in the United States. This article will look into the challenges around development and manufacturing that need to be addressed so that ambitious pharma and biotechs can continue to develop these innovative medicines. 


Cell & Gene Therapy: European Heatmap

Cell & Gene Therapy: European Heatmap

The cell and gene therapy manufacturing sphere continues to mature rapidly, with a growing number of companies moving towards commercialising products. This infographic provides a high level overview of the latest developments in the European cell and gene therapy manufacturing space, looking at which therapies are moving into commercialisation in order to treat a wide range of conditions and diseases.

Making Medicines of The Future

Making Medicines of The Future

In this case study, Pharma IQ gains insight from Oxford BioMedica - a pioneer in the development of gene therapies for 20 years, focused mainly on lentiviral vectors. The ebook evaluates manufacturing trends, preparing for the commercial phases of gene therapies, combating extractables and leachables and scaling up. 
 
Cell And Gene Manufacturing UK Heatmap

Cell And Gene Manufacturing UK Heatmap

In response to the region’s strengthening presence with the therapeutic method, Pharma IQ presents this Cell and Gene Manufacturing hotspot map.

Cell and Gene Therapy Europe Heatmap

Cell and Gene Therapy Europe Heatmap

Over the last 12 months, the cell and gene therapy manufacturing sphere has matured vastly with more companies advancing to commercial products, especially with allogenic therapies. Now that the theory behind the therapy is catching up with the technology, the two can come together to progress towards producing commercial products. In this Cell and Gene Manufacturing hotspot map,  we have broadened our focus to scan the cell and gene manufacturing activity that is occurring across Europe regarding the road to commercialised therapies.
Producing Off-The-Shelf Cell and Gene Products

Producing Off-The-Shelf Cell and Gene Products

The rise of personalised medicines has led to the focus on small scale manufacture with a key challenge being that lots of the same element will run through a facility at once. Randomised trials with complex gene therapies- which target a small number of patients often in regards to orphan diseases can encounter various manufacturing hurdles. Also, evidence is needed to prove efficacy against historical controls with Phase II trials. This of course requires several years of data which is limited, incurring implications on cost and time to market. Ahead of the Cell and Gene Therapy Manufacturing conference Pharma IQ examines the various challenges that complicate the route to producing off the shelf cell and gene products.